Volume 21, Issue 8 e202301944
Research Article

Beta vulgaris L. var cicla Decreases Liver Injury Induced by Antiarrhytmic Agent, Amiodarone

Dr. Ismet Burcu Turkyilmaz

Corresponding Author

Dr. Ismet Burcu Turkyilmaz

Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, Avcilar, Istanbul, Türkiye

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Dr. Serap Sancar

Dr. Serap Sancar

Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Türkiye

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Prof. Dr. Sehnaz Bolkent

Prof. Dr. Sehnaz Bolkent

Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Türkiye

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Prof. Dr. Refiye Yanardag

Prof. Dr. Refiye Yanardag

Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, Avcilar, Istanbul, Türkiye

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First published: 07 June 2024

Abstract

Amiodarone (AMD) is an effective antiarrhythmic drug, but its long-term usage strongly forms liver toxicity due to its accumulation tendency. The chard (Beta vulgaris L. var. cicla) is a unique plant which has a blood sugar-lowering effect and powerful antioxidant activity. The aim of the current study was to investigate the possible protective effects of chard on AMD-induced liver injury. Male Sprague-Dawley rats were divided into four groups. Control group, aqueous chard extract given group 500 mg/kg/day for one week, AMD given group 100 mg/kg/day for one week, AMD+Chard given group (at the same doses and times). They were sacrificed on the 8th day. The blood and liver samples were taken. The serum and liver biochemical parameters were found to be changed in AMD treated group. Chard administration reversed these parameters in serum and liver. In histological experiments, necrotic areas, mononuclear cell infiltration, the endothelial rupture in central vein, sinusoidal dilatation, hyperemia, dark eosinophilic cells and picnotic nucleus were observed in liver tissues of AMD treated group. Chard treatment reduced liver tissue damage. Considering results, we can suggest that chard prevented AMD induced liver injury biochemically and histologically.

Graphical Abstract

Conflict of Interests

The authors declare no conflict of interest.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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