Development of the PTSD-Repository: A Publicly Available Repository of Randomized Controlled Trials for Posttraumatic Stress Disorder
This project was funded by the Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health and Human Services (HHS; HHSA290201500009I, Task Order 12) as well as the U. S. Department of Veterans Affairs, Veterans Health Administration (VHA), Office of Research and Development, Rehabilitation Research and Development Service (RR&D), and the Health Services Research and Development Service (HSR&D) Center to Improve Veteran Involvement in Care (CIVIC Grant Number I50 HX001244-01). Dr. O'Neil's work was supported in part by a Career Development Award from the VHA RR&D (1 IK2 RX002762-01A1).
The U.S. Department of Veterans Affairs had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. The findings and conclusions in this document are those of the authors who are responsible for its contents; the findings and conclusions do not necessarily represent the views of the U.S. Department of Veterans Affairs or the United States’ government. The authors of this manuscript are responsible for its content. Statements in the manuscript do not necessarily represent the official views of or imply endorsement by AHRQ or HHS.
Abstract
enGiven the extensive research on posttraumatic stress disorder (PTSD) treatment, a single, updatable repository of data from PTSD treatment studies would be useful for clinical, research, and policy stakeholders. To meet this need, we established a preliminary dataset of abstracted PTSD trial data, which serve as the basis for the PTSD Trials Standardized Data Repository (PTSD-Repository), maintained by the National Center for PTSD (NCPTSD). We followed systematic review methods to identify published randomized controlled trials (RCTs) of PTSD interventions. We consulted with a panel of experts to determine a priori inclusion criteria, ensure that we captured all relevant studies, and identify variables for abstraction. We searched multiple databases for materials published from 1980 to 2018 and reviewed reference lists of relevant systematic reviews and clinical practice guidelines. In total, 318 RCTs of PTSD interventions that enrolled almost 25,000 participants were included. We abstracted 337 variables across all studies, including study, participant, and intervention characteristics as well as results. In the present paper, we describe our methods and define data elements included in the data tables. We explain coding challenges, identify inconsistencies in reporting across study types, and discuss ways stakeholders can use PTSD-Repository data to enhance research, education, and policy. The abstracted data are currently publicly available on the NCPTSD website and can be used for future systematic reviews and identifying research gaps and as an information resource for clinicians, patients, and family members.
Resumen
esSpanish Abstracts by Asociación Chilena de Estrés Traumático (ACET)
Desarrollo del Repositorio de TEPT: Un Repositorio Disponible Públicamente de Ensayos Controlados Aleatorios para el Trastorno de Estrés Postraumático
DESARROLLO DEL REPOSITORIO DE TEPT
Dada la extensa investigación sobre el tratamiento del trastorno de estrés postraumático (TEPT), un depósito único y actualizable de datos de los estudios de tratamiento del TEPT sería útil para las partes interesadas clínicos, investigación y políticas. Para satisfacer esta necesidad, establecimos un conjunto de datos preliminares de datos de ensayos de TEPT resumidos, que sirven como base para el Repositorio de Datos Estandarizados de Ensayos de TEPT (Repositorio de TEPT o PTSD-Repository en su sigla en inglés), mantenido por el Centro Nacional para TEPT (NCPTSD en su sigla en inglés). Seguimos métodos de revisión sistemática para identificar ensayos controlados aleatorios (ECA) publicados de intervenciones de TEPT. Consultamos con un panel de expertos para determinar a priori los criterios de inclusión, asegurándonos de capturar todos los estudios relevantes e identificar las variables para su extracción. Buscamos en múltiples bases de datos los materiales publicados entre 1980 y 2018 y revisamos listas de referencias de revisiones sistemáticas relevantes y guías de práctica clínica. En total, se incluyeron 318 ECA de intervenciones de TEPT que reclutaron a casi 25 000 participantes. Resumimos 337 variables en todos los estudios, incluidas las características del estudio, el participante y la intervención, así como los resultados. En el presente artículo, describimos nuestros métodos y definimos los elementos de datos incluidos en las tablas de datos. Explicamos los desafíos de codificación, identificamos inconsistencias en los informes entre los tipos de estudios y discutimos las formas en que las partes interesadas pueden usar los datos del Repositorio de TEPT para mejorar la investigación, la educación y las políticas. Los datos resumidos están actualmente disponibles públicamente en el sitio web de NCPTSD y se pueden usar para futuras revisiones sistemáticas e identificar brechas de investigación y como un recurso de información para médicos, pacientes y miembros de la familia.
抽象
zhDevelopment of the PTSD-Repository: A Publicly Available Repository of Randomized Controlled Trials for Posttraumatic Stress Disorder
Abstract
Given the extensive research on posttraumatic stress disorder (PTSD) treatment, a single, updatable repository of data from PTSD treatment studies would be useful for clinical, research, and policy stakeholders. To meet this need, we established a preliminary dataset of abstracted PTSD trial data, which serve as the basis for the PTSD Trials Standardized Data Repository (PTSD-Repository), maintained by the National Center for PTSD (NCPTSD). We followed systematic review methods to identify published randomized controlled trials (RCTs) of PTSD interventions. We consulted with a panel of experts to determine a priori inclusion criteria, ensure that we captured all relevant studies, and identify variables for abstraction. We searched multiple databases for materials published from 1980 to 2018 and reviewed reference lists of relevant systematic reviews and clinical practice guidelines. In total, 318 RCTs of PTSD interventions that enrolled almost 25,000 participants were included. We abstracted 337 variables across all studies, including study, participant, and intervention characteristics as well as results. In the present paper, we describe our methods and define data elements included in the data tables. We explain coding challenges, identify inconsistencies in reporting across study types, and discuss ways stakeholders can use PTSD-Repository data to enhance research, education, and policy. The abstracted data are currently publicly available on the NCPTSD website and can be used for future systematic reviews and identifying research gaps and as an information resource for clinicians, patients, and family members.
PTSD資料庫的開發: 創傷後壓力症的隨機對照試驗公開資料庫
摘要
鑑於對創傷後壓力症(PTSD)治療的廣泛研究, 創傷後壓力症治療研究的單一、可更新的數據存儲將對臨床、研究和政策利益相關者有用。為了滿足這一需求, 我們建立了初步的創傷後壓力症試驗數據集, 作為創傷後壓力症試驗標準化數據庫(PTSD標準化數據庫)的基礎, 該數據庫由國家創傷後壓力症中心(NCPTSD)管理。我們採用系統回顧的方法來確定已發表的創傷後壓力症干預措施的隨機對照試驗(RCTs)。我們諮詢了一組專家, 確定先驗的納入標準, 確保我們掌握了所有相關的研究, 並確定摘要的變量。我們搜索了
多個數據庫, 查閱1980年至2018年發表的材料, 以及相關系統綜述和臨床實踐指南的參考文獻列表。總共納入了318項關於創傷後壓力症干預的隨機對照試驗, 總招募參與者近25000名。我們從所有的研究中摘錄了337個變量, 包括研究、參與者和干預特徵以及結果。在本文中, 我們描述了我們的方法並定義了數據表中包含的數據元素。我們解釋了編碼方面的挑戰, 確定了不同研究類型報告中的不一致之處, 並討論了利益相關者如何使用PTSD標準化數據庫的數據來加強研究、教育和政策。這些摘要數據目前可在國家創傷後壓力症中心(NCPTSD)的網站上公開獲取, 可用於未來的系統審閱和確定研究差距, 並作為臨床治療者、患者及家屬的信息資源。
