Can radiographic patellofemoral osteoarthritis be diagnosed using clinical assessments?
Corresponding Author
Jade M. Tan
Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Correspondence
Jade M Tan, Discipline of Podiatry and La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne 3086, Australia.
Email: jade.tan@latrobe.edu.au
Search for more papers by this authorHylton B. Menz
Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorShannon E. Munteanu
Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorNatalie J. Collins
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorHarvi F. Hart
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Department of Physical Therapy, Faculty of Health Sciences, Collaborative Training Program in Musculoskeletal Health Research, and Bone and Joint Institute, The University of Western Ontario, London, Canada
Search for more papers by this authorJoel W. Donnar
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorGearoid Cleary
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorIsobel C. O'Sullivan
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorLiam R. Maclachlan
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorCatherine L. Derham
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorKay M. Crossley
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorCorresponding Author
Jade M. Tan
Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Correspondence
Jade M Tan, Discipline of Podiatry and La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne 3086, Australia.
Email: jade.tan@latrobe.edu.au
Search for more papers by this authorHylton B. Menz
Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorShannon E. Munteanu
Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorNatalie J. Collins
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorHarvi F. Hart
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Department of Physical Therapy, Faculty of Health Sciences, Collaborative Training Program in Musculoskeletal Health Research, and Bone and Joint Institute, The University of Western Ontario, London, Canada
Search for more papers by this authorJoel W. Donnar
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorGearoid Cleary
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorIsobel C. O'Sullivan
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorLiam R. Maclachlan
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Search for more papers by this authorCatherine L. Derham
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorKay M. Crossley
La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia
Search for more papers by this authorAbstract
Introduction
The aim of this study was to determine whether participant characteristics and clinical assessments could identify radiographic osteoarthritis (OA) in individuals with clinically diagnosed, symptomatic patellofemoral osteoarthritis (PFOA).
Methods
Participant characteristics and clinical assessments were obtained from 179 individuals aged 50 years and over with clinically diagnosed symptomatic PFOA, who were enrolled in a randomised trial. Anteroposterior, lateral, and skyline X-rays were taken of the symptomatic knee. The presence of radiographic PFOA was defined as “no or early PFOA” (Kellgren and Lawrence [KL] grade ≤1 in the PF compartment) or “definite PFOA” (KL grade ≥2). Diagnostic test statistics were applied to ascertain which participant characteristics and clinical assessments could identify the presence of definite radiographic PFOA.
Results
A total of 118 participants (66%) had definite radiographic PFOA. Univariate analysis identified that older age (>61 years), female sex, higher body mass index (BMI) (>29 kg/m2), longer pain duration (>2.75 years), higher maximum knee pain during stair ambulation (>47/100 mm), and fewer repeated single step-ups to pain onset (<21) were associated with the presence of definite radiographic PFOA. Multivariate logistic regression indicated that BMI, pain duration, and repeated single step-ups to pain onset were independently associated with radiographic PFOA and identified the presence of definite radiographic PFOA with an overall accuracy of 73%.
Conclusion
In individuals over 50 years of age with a clinical diagnosis of PFOA, higher BMI, longer pain duration, and fewer repeated single step-ups to pain onset increased the likelihood of radiographic PFOA. However, overall diagnostic accuracy was modest, suggesting that radiographic PFOA cannot be confidently identified using these tests.
CONFLICT OF INTEREST
None of the authors have a competing interest to declare.
REFERENCES
- Arden, N., & Nevitt, M. C. (2006). Osteoarthritis: epidemiology. Best Practice & Research. Clinical Rheumatology, 20(1), 3–25. https://doi.org/10.1016/j.berh.2005.09.007
- Baker, K. R., Xu, L., Zhang, Y., Nevitt, M., Niu, J., Aliabadi, P., … Felson, D. (2004). Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study. Arthritis and Rheumatism, 50(6), 1815–1821. https://doi.org/10.1002/art.20261
- Bedson, J., & Croft, P. R. (2008). The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskeletal Disorders, 9(116). https://doi.org/10.1186/1471-2474-9-116
- Bujang, M. A., & Adnan, T. H. (2016). Requirements for minimum sample size for sensitivity and specificity analysis. Journal of Clinical and Diagnostic Research, 10(10), YE01–YE06. https://doi.org/10.7860/JCDR/2016/18129.8744
- Collins, N. J., Oei, E. H., de Kanter, J. L., Vicenzino, B., & Crossley, K. M. (2019). Prevalence of radiographic and MRI features of patellofemoral osteoarthritis in young and middle-aged adults with persistent patellofemoral pain. Arthritis Care and Research, 71(8), 1068–1073. https://doi.org/10.1002/acr.23726
10.1002/acr.23726 Google Scholar
- Collins, N. J., Tan, J. M., Menz, H. B., Russell, T. G., Smith, A. J., Vicenzino, B., … Crossley, K. M. (2019). The FOOTPATH study: protocol for a multicentre, participant- and assessor-blind, parallel group randomised clinical trial of foot orthoses for patellofemoral osteoarthritis. BMJ Open, 9, e025315. https://doi.org/10.1136/bmjopen-2018-025315
- Crema, M. D., Guermazi, A., Sayre, E. C., Roemer, F. W., Wong, H., Thorne, A., … Cibere, J. (2011). The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: the MoDEKO study. Osteoarthritis and Cartilage, 19(12), 1429–1432. https://doi.org/10.1016/j.joca.2011.09.003
- Crossley, K. M., Bennell, K. L., Cowan, S. M., & Green, S. (2004). Analysis of outcome measures for persons with patellofemoral pain: which are reliable and valid? Archives of Physical Medicine and Rehabilitation, 85(5), 815–822. https://doi.org/10.1016/S0003-9993(03)00613-0
- Culvenor, A. G., Cook, J. L., Collins, N. J., & Crossley, K. M. (2013). Is patellofemoral joint osteoarthritis an under-recognised outcome of anterior cruciate ligament reconstruction? A narrative literature review. British Journal of Sports Medicine, 47(2), 66–70. https://doi.org/10.1136/bjsports-2012-091490
- Freedman, D. A. (1983). A note on screening regression equations. The American Statistician, 37(2), 152–155. https://doi.org/10.1080/00031305.1983.10482729
- Hart, D., & Spector, T. (2003). Kellgren & Lawrence grade 1 osteophytes in the knee—doubtful or definite? Osteoarthritis and Cartilage, 11(2), 149–150. https://doi.org/10.1053/joca.2002.0853
- Hart, H. F., Barton, C. J., Khan, K. M., Riel, H., & Crossley, K. M. (2017). Is body mass index associated with patellofemoral pain and patellofemoral osteoarthritis? A systematic review and meta-regression and analysis. British Journal of Sports Medicine, 51(10), 781–790. https://doi.org/10.1136/bjsports-2016-096768
- Hart, H. F., Filbay, S. R., Coburn, S., Charlton, J. M., Sritharan, P., & Crossley, K. M. (2018). Is quality of life reduced in people with patellofemoral osteoarthritis and does it improve with treatment? A systematic review, meta-analysis and regression. Disability and Rehabilitation, 44(25), 1–15. https://doi.org/10.1080/09638288.2018.1482504
- Hart, H. F., Stefanik, J. J., Wyndow, N., Machotka, Z., & Crossley, K. M. (2017). The prevalence of radiographic and MRI-defined patellofemoral osteoarthritis and structural pathology: a systematic review and meta-analysis. British Journal of Sports Medicine, 51(16), 1195–1208. https://doi.org/10.1136/bjsports-2017-097515
- Hart, H. F., van Middelkoop, M., Stefanik, J. J., Crossley, K. M., & Bierma-Zeinstra, S. (2019). Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study. Rheumatology International, 40, 227–232. https://doi.org/10.1007/s00296-019-04472-9
- Hendry, M., Williams, N. H., Markland, D., Wilkinson, C., & Maddison, P. (2006). Why should we exercise when our knees hurt? A qualitative study of primary care patients with osteoarthritis of the knee. Family Practice, 23(5), 558–567. https://doi.org/10.1093/fampra/cml022
- Herbert, R., Jamtvedt, G., Mead, J., & Hagen, K. B. (2005). Practical Evidence-Based Physiotherpay-E-book. United Kingdom: Elseiver Health Sciences.
- Hinman, R. S., Lentzos, J., Vicenzino, B., & Crossley, K. M. (2014). Is patellofemoral osteoarthritis common in middle-aged people with chronic patellofemoral pain? Arthritis Care and Research, 66(8), 1252–1257. https://doi.org/10.1002/acr.22274
10.1002/acr.22274 Google Scholar
- Kellgren, J., & Lawrence, J. (1957). Radiological assessment of osteo-arthrosis. Annals of the Rheumatic Diseases, 16(4), 494–503. https://doi.org/10.1136/ard.16.4.494
- Kornaat, P. R., Bloem, J. L., Ceulemans, R. Y., Riyazi, N., Rosendaal, F. R., Nelissen, R. G., … Kloppenburg, M. (2006). Osteoarthritis of the knee: association between clinical features and MR imaging findings. Radiology, 239(3), 811–817. https://doi.org/10.1148/radiol.2393050253
- Lankhorst, N., van Middelkoop, M., Crossley, K., Bierma-Zeinstra, S., Oei, E., Vicenzino, B., & Collins, N. (2016). Factors that predict a poor outcome 5–8 years after the diagnosis of patellofemoral pain: a multicentre observational analysis. British Journal of Sports Medicine, 50(14), 881–886. https://doi.org/10.1136/bjsports-2015-094664
- Mäenpää, H., & Lehto, M. U. (1997). Patellofemoral osteoarthritis after patellar dislocation. Clinical Orthopaedics and Related Research, 339, 156–162.
10.1097/00003086-199706000-00021 Google Scholar
- Messier, S. P., Mihalko, S. L., Legault, C., Miller, G. D., Nicklas, B. J., DeVita, P., … Eckstein, F. (2013). Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. Journal of the American Medical Association, 310(12), 1263–1273. https://doi.org/10.1001/jama.2013.277669
- National Institute for Health and Care Excellence. (2014). Osteoarthritis: care and management. Retrieved from https://www.nice.org.uk/guidance/cg177/chapter/1-Recommendations#diagnosis-2
- Nunes, G. S., Stapait, E. L., Kirsten, M. H., de Noronha, M., & Santos, G. M. (2013). Clinical test for diagnosis of patellofemoral pain syndrome: systematic review with meta-analysis. Physical Therapy in Sport, 14(1), 54–59. https://doi.org/10.1016/j.ptsp.2012.11.003
- Patterson, B. E., Culvenor, A. G., Barton, C. J., Guermazi, A., Stefanik, J. J., Morris, H. G., … Crossley, K. M. (2018). Worsening knee osteoarthritis features on magnetic resonance imaging 1 to 5 years after anterior cruciate ligament reconstruction. The American Journal of Sports Medicine, 46(12), 2873–2883. https://doi.org/10.1177/0363546518789685
- Peat, G., Duncan, R. C., Wood, L. R., Thomas, E., & Muller, S. (2012). Clinical features of symptomatic patellofemoral joint osteoarthritis. Arthritis Research & Therapy, 14(2), R63. https://doi.org/10.1186/ar3779
- Pollard, T., Gwilym, S., & Carr, A. (2008). The assessment of early osteoarthritis. The Journal of Bone and Joint SurgeryBritish Volume, 90(4), 411–421. https://doi.org/10.1302/0301-620X.90B4.20284
- Schiphof, D., van Middelkoop, M., de Klerk, B. M., Oei, E., Hofman, A., Koes, B. W., … Bierma-Zeinstra, S. M. (2014). Crepitus is a first indication of patellofemoral osteoarthritis (and not of tibiofemoral osteoarthritis). Osteoarthritis and Cartilage, 22(5), 631–638. https://doi.org/10.1016/j.joca.2014.02.008
- Stefanik, J., Duncan, R., Felson, D., & Peat, G. (2018). Diagnostic performance of clinical examination measures and pain presentation to identify patellofemoral joint osteoarthritis. Arthritis Care and Research, 70(1), 157–161. https://doi.org/10.1002/acr.23238
- Stefanik, J. J., Guermazi, A., Zhu, Y., Zumwalt, A. C., Gross, K. D., Clancy, M., … Roemer, F. W. (2011). Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis. Arthritis Care and Research, 63(10), 1391–1397. https://doi.org/10.1002/acr.20528
10.1002/acr.20528 Google Scholar
- Stefanik, J. J., Neogi, T., Niu, J., Roemer, F. W., Segal, N. A., Lewis, C. E., … Felson, D. T. (2014). The diagnostic performance of anterior knee pain and activity-related pain in identifying knees with structural damage in the patellofemoral joint: the Multicenter Osteoarthritis Study. The Journal of Rheumatology, 14(8), 1696–1702. https://doi.org/10.3899/jrheum.131555
- Sutton, A. J., Muir, K. R., & Jones, A. C. (1997). Two knees or one person: data analysis strategies for paired joints or organs. Annals of the Rheumatic Diseases, 56(7), 401–402. https://doi.org/10.1136/ard.56.7.401
- Tabachnick, B. G., & Fidell, L. S. (2006). Using multivariate statistics ( 5th ed.). Needham Heights, MA: Allyn & Bacon, Inc.
- Thomas, M. J., Wood, L., Selfe, J., & Peat, G. (2010). Anterior knee pain in younger adults as a precursor to subsequent patellofemoral osteoarthritis: a systematic review. BMC Musculoskeletal Disorders, 11(1), 201–209. https://doi.org/10.1186/1471-2474-11-201
- Treede, R.-D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., … Wang, S.-J. (2015). A classification of chronic pain for ICD-11. Pain, 156(6), 1003–1007. https://doi.org/10.1097/j.pain.0000000000000160
- van Middelkoop, M., Bennell, K. L., Callaghan, M. J., Collins, N. J., Conaghan, P. G., Crossley, K. M., … Hunter, D. J. (2017). International patellofemoral osteoarthritis consortium: consensus statement on the diagnosis, burden, outcome measures, prognosis, risk factors and treatment. Seminars in Arthritis and Rheumatism, 47, 666–675. https://doi.org/10.1016/j.semarthrit.2017.09.009
- Vicenzino, B., Collins, N. J., Crossley, K. M., Beller, E., Darnell, R., & McPoil, T. G. (2008). Foot orthoses and physiotherapy in the treatment of patellofemoral pain syndrome: a randomised clinical trial. BMC Musculoskeletal Disorders, 9(1), 27–39. https://doi.org/10.1186/1471-2474-9-27
- Wyndow, N., Collins, N. J., Vicenzino, B., Tucker, K., & Crossley, K. M. (2016). Is there a biomechanical link between patellofemoral pain and osteoarthritis? A narrative review. Sports Medicine, 46(12), 1797–1808. https://doi.org/10.1007/s40279-016-0545-6