Deferoxamine pretreatment inhibits metal neurotoxicity in Caenorhabditis elegans
Carla Alves
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorNatália Piva Zancan
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorAni Carla Concato
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Postgraduate Program in Environmental Science and Technology, Federal University of Southern Frontier (UFFS), Campus Erechim/RS, Erechim/RS/Brazil, Erechim, RS, Brasil
Search for more papers by this authorAna Paula Vanin
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorWagner A. Tamagno
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorDiego Tessaro
Postgraduate Program in Environmental Science and Technology, Federal University of Southern Frontier (UFFS), Campus Erechim/RS, Erechim/RS/Brazil, Erechim, RS, Brasil
Search for more papers by this authorCorresponding Author
Rosilene R. Kaizer
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Postgraduate Program in Environmental Science and Technology, Federal University of Southern Frontier (UFFS), Campus Erechim/RS, Erechim/RS/Brazil, Erechim, RS, Brasil
Correspondence
Rosilene R. Kaizer, Rodovia RS 135, Km 25, Distrito Engenheiro Luiz Englert, CEP 99170, Sertão, RS, Brasil.
Email: rosikaizer@gmail.com; rosilene.perin@sertao.ifrs.edu.br
Search for more papers by this authorCarla Alves
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorNatália Piva Zancan
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorAni Carla Concato
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Postgraduate Program in Environmental Science and Technology, Federal University of Southern Frontier (UFFS), Campus Erechim/RS, Erechim/RS/Brazil, Erechim, RS, Brasil
Search for more papers by this authorAna Paula Vanin
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorWagner A. Tamagno
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Search for more papers by this authorDiego Tessaro
Postgraduate Program in Environmental Science and Technology, Federal University of Southern Frontier (UFFS), Campus Erechim/RS, Erechim/RS/Brazil, Erechim, RS, Brasil
Search for more papers by this authorCorresponding Author
Rosilene R. Kaizer
Federal Institute of Education, Science and Technology of Rio Grande do Sul – IFRS Campus Sertão, Sertão, RS, Brasil
Postgraduate Program in Environmental Science and Technology, Federal University of Southern Frontier (UFFS), Campus Erechim/RS, Erechim/RS/Brazil, Erechim, RS, Brasil
Correspondence
Rosilene R. Kaizer, Rodovia RS 135, Km 25, Distrito Engenheiro Luiz Englert, CEP 99170, Sertão, RS, Brasil.
Email: rosikaizer@gmail.com; rosilene.perin@sertao.ifrs.edu.br
Search for more papers by this authorAbstract
Neurodegenerative diseases are increasingly common in humans. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of extracellular plaques containing β-amyloid peptides and neurofibrillary tangles in the brains. Researchers have focused on the elucidation of a correlation between high concentrations of aluminum or iron (in the organism with observed neuropathology). The objective of this study was to evaluate the effects of aluminum and iron on the behavioral parameters (pharyngeal pumping and defecation cycle) of the nematode Caenorhabditis elegans pretreated with deferoxamine (DFX). Acetylcholinesterase (AChE) activity was evaluated as well. DFX is a chelant that is widely used for the treatment of metal toxicity, and it has a high affinity for aluminum and iron. The worms were pretreated with DFX, and then exposed to aluminum and iron. In the absence of DFX, aluminum exposure decreased pharyngeal pumping compared with that in the control group. The defecation cycle of the control was significantly different from that of the worms exposed to aluminum. In contrast, an increased defecation cycle was observed in worms exposed to iron without DFX pretreatment. AChE activity increased in aluminum-exposed groups that received DFX pretreatment compared with those that did not receive pretreatment. These results suggest that pretreatment with DFX is effective in reducing metal toxicity, particularly with reference to AChE activity, which did not decrease in groups that did not receive DFX pretreatment.
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