Volume 27, Issue 3 p. 229-236
ORIGINAL RESEARCH

Transcatheter aortic valve implantation for severe aortic stenosis in the Australian regional population

Sarang Paleri MD, BBiomed

Sarang Paleri MD, BBiomed

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Jodie Li-Mei Tham MD, BSc

Jodie Li-Mei Tham MD, BSc

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia

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David Jin MD, BBiomed

David Jin MD, BBiomed

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Yee Sen Chan MBBS

Yee Sen Chan MBBS

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Christine Wright RN

Christine Wright RN

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Arul Baradi MBChB

Arul Baradi MBChB

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Robert J. Whitbourn MBBS, BMedSc, BSc(Hons), FRACP, FCSANZ

Robert J. Whitbourn MBBS, BMedSc, BSc(Hons), FRACP, FCSANZ

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Heath S. L. Adams MBBS (Hons), BMedSci

Heath S. L. Adams MBBS (Hons), BMedSci

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Faculty of Health Science, University of Tasmania, Hobart, Tasmania, Australia

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Sonny C. Palmer BA, BSc, MBBS, DMedSci, FRACP, FCSANZ

Corresponding Author

Sonny C. Palmer BA, BSc, MBBS, DMedSci, FRACP, FCSANZ

Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia

Correspondence

Dr Sonny C. Palmer, Department of Cardiology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.

Email: sonny.palmer@svha.org.au

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First published: 10 May 2019
Citations: 5

Abstract

Objective

To compare clinical and functional outcomes of regional and urban patients after transcatheter aortic valve implantation for severe aortic stenosis.

Methods

Data were collected at patient follow-up post-transcatheter aortic valve implantation at 30 days and 12 months. Patients were stratified by residential postcodes into remoteness areas using the Australian Statistical Geography Standard.

Design

Retrospective cohort study.

Setting

Single-centre tertiary referral hospital.

Participants

Patients undergoing transcatheter aortic valve implantation (n = 142) from 2009 to 2018 were analysed, with 77 patients (54.2%) residing in regional Victoria and New South Wales.

Main outcome measures

Procedural success, adverse event rates, readmission rates, mortality rates, loss to follow-up and functional improvement.

Results

Patients residing in regional areas had a lower mean age (81.8 vs 83.7 years) and proportion of Stage 4 or 5 chronic kidney disease (1.3% vs 9.2%), compared with urban patients. Procedural characteristics and immediate post-procedural outcomes were similar between both groups. There was no statistically significant difference in mortality, readmission rates or loss to follow-up between the two cohorts. Regional patients demonstrated poorer rates of functional improvement at 30 days (50.7% vs 67.7%); however, this difference was not sustained at 12 months (79.2% vs 71.0%). Frailty was demonstrated to be an independent predictor of poor 30-day functional improvement.

Conclusion

Regional patients treated with transcatheter aortic valve implantation for severe aortic stenosis have non-inferior 30-day and 12-month outcomes, when compared with urban patients. Frailty is a predictor of poor functional improvement post-transcatheter aortic valve implantation.

CONFLICTS OF INTEREST

None.

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