Editor-in-Chief Dr. Marc Veldhoen, Institute for Molecular Medicine, University of Lisbon, Portugal
About This Journal
Meet the Editor
Marc Veldhoen studied Medical Biology at Utrecht University, and then moved to National Institute for Medical Research (Mill Hill), UK. From 2010 to 2016 he was a group leader at the Babraham Institute in Cambridge, UK. He was awarded a prestigious ERC consolidator grant and was selected for the European Molecular Biology Organisation young investigator programme. In 2016 he moved to the Instituto de Medicina Moledular (iMM) in Lisbon, Portugal as the European Research Area chair. Where from 2018 he took up a position as professor of basic immunology at the Faculty of Medicine, University of Lisbon. His lab focus is T cell biology, with wide ranging interests from development and activation to differentiation, maintenance and metabolism. He made seminal contributions to CD4 T cell biology, such as the differentiation of Th17 and Th9 cells, and the role of the arylhydrocarbon receptor (AhR) in T cell biology. A large part of the lab is now dedicated to tissue resident T cells and the mechanisms that control their development, maintenance and activation. The clinical benefits are targeting the prevention of undesirable immune responses that may result in chronic infections, allergies and autoimmunity as well as strengthening our own immune responses against infection, such as using vaccination, as well as against tumours.
Articles
Exosomes secreted from induced pluripotent stem cell ameliorate the lipopolysaccharide induced neuroinflammatory response via lncRNA‐0949
-  27 March 2024
Case report: Systemic lupus erythematosus combined with myocardial hypertrophy
-  27 March 2024
Preventing breast milk HIV transmission using broadly neutralizing monoclonal antibodies: One size does not fit all
-  27 March 2024
Key messages
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Passive immunoprophylaxis with broadly neutralizing monoclonal antibodies (bNAbs) could be a game changer in the prevention of human immunodeficiency virus (HIV) acquisition.
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The prevailing view is that available resources should be focused on identifying a fixed combination of at least three bNAbs for universal use in therapeutic and preventive protocols, regardless of target populations or routes of transmission.
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HIV transmission through breastfeeding is unique: it involves free viral particles and cell-associated virus from breast milk and, in the case of acute/recent maternal infection, a viral population with restricted Env diversity.
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HIV transmission through breastfeeding in high incidence/prevalence areas could potentially be eliminated by subcutaneous administration to all newborns of one or two long-acting bNAbs with extended breadth, high potency, and effector properties (ADCC, phagocytosis) against circulating HIV strains.
Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice
-  27 March 2024
Unveiling global research trends and hotspots on mitochondria in NAFLD from 2000 to 2023: A bibliometric analysis
-  27 March 2024
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
Association between HLA gene polymorphisms and mortality of COVID‐19: An in silico analysis
-  684-694
-  13 October 2020
Graphical Abstract
We conducted in silico analyses and examined an association of HLA gene polymorphisms with prevalence and mortality of COVID-19 by using publicly available databases. We found that the association between HLA-A*02:01 and increased risk for COVID-19 is probably due to the lower capacity of the genotype to present SARS-CoV-2 antigens. Our study suggests that identifying the HLA genotype associated with the severity of COVID-19 or susceptibility to SARS-CoV-2 may support future vaccination strategies to genotypically at-risk populations.
Does COVID‐19 contribute to development of neurological disease?
-  48-58
-  17 December 2020
Graphical Abstract
This review correlates present clinical manifestations of coronavirus disease 2019 patients with possible neurological consequences. Recent studies suggest that activated glial cells contribute to neuroinflammation and the devastating effects of severe acute respiratory syndrome coronavirus 2 infection on the central nervous system.
Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease
-  59-73
-  17 December 2020
Graphical Abstract
Obesity plays a vital role in the development of associated nonalcoholic fatty liver disease by affecting several inflammatory reactions via adipose tissue, vascular, intestinal, skeletal muscle, and brain, this process is associated with adipose tissue inflammation, inflammatory factors in the blood, intestinal inflammation, skeletal muscle inflammation, and brain tissue inflammation.
The relationship between COVID‐19 viral load and disease severity: A systematic review
-  13 December 2021
Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps
-  233-243
-  19 April 2017
Graphical Abstract
ILC2s were elevated in CRSwNP and expressions of inducible T-cell co-stimulator (ICOS) and CD127 in ILC2s were altered in CRSwNP compared to blood or tonsil ILC2. In addition, sorted CRSwNP ILC2 but not blood ILC2 spontaneously released type 2 cytokines including IL-5 and IL-13. These results suggest that ILC2s are not only elevated but also activated in CRSwNP in vivo.
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Recent issues
- Volume 12, Issue 3March 2024
- Volume 12, Issue 2February 2024
- Volume 12, Issue 1January 2024
- Volume 11, Issue 12December 2023
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