Highlights

• Six microRNAs (miR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b) were selected as potential circulating biomarkers of type 2 diabetes mellitus (T2DM).
• MiR-146a and miR-21 were identified as potential tissue biomarkers of T2DM.

Highlights

• Based on nationwide insurance data in Korea, the use of dipeptidyl peptidase IV inhibitors (DPP-IVi) not requiring renal dose adjustment (NRDA DPP-IVi) is widespread in the type 2 diabetes chronic kidney disease (T2D CKD) population.
• Instead of prescribing NRDA DPP-IVi, the use of DPP-IVi requiring renal dose adjustment with appropriate renal dose adjustments in T2D CKD patients can achieve a considerable annual cost saving of up to 7.8%.

Highlights

• Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2; recent modeling of the structure of SARS-CoV-2 spike glycoprotein, which mediates viral-host-cell entry, predicts interactions with dipeptidyl peptidase 4 (DPP4) in addition to angiotensin-converting enzyme 2.
• Increased DPP4 expression and activity are associated with diabetes, obesity, and metabolic syndrome, all of which have been reported to influence COVID-19 severity.
• DPP4 inhibitors (gliptins), which vary in their interactions with the active site of the enzyme, may have immunomodulatory and cardioprotective effects that could be beneficial in COVID-19 cases.

Highlights

• Hydroxychloroquine (HCQ) has been shown to exert antihyperglycemic properties by virtue of potential multifaceted effects on glucose homeostasis, including improvement of insulin sensitivity, increase of insulin secretion, and reduction of systemic inflammation.
• Preliminary studies have shown the safety and efficacy of HCQ as an antihyperglycemic agent in type 2 diabetes over a short-term period.
• A careful risk-benefit assessment of HCQ is critical for a cautious use of this drug in diabetic patients, particularly in light of the current COVID-19 pandemic.

Highlights

• Provide key information on the 6-month dose of basal insulin (BI) needed for effective glycemic control in Chinese type 2 diabetes melliuts (T2DM) patients.
• High body mass index, high fasting plasma glucose, young age, longer duration of diabetes are some of the crucial determinants of the 6-month dose of BI in a real-world setting.

Highlights

• There are variations in diabetes-related hospitalizations that stem from emergency department visits.
• Rural residents, racial and ethnic minorities, the uninsured, and residents of the South and Midwest census regions of the United States are more likely to seek emergency care and be admitted for treatment of a primary diabetes diagnosis.
• Future research should continue to explore the effective interventions and services that can be offered to address the current health inequities facing at-risk populations.