Highlights

• This is the first multicenter, large-sample and cross-sectional study of the relationship between RC and urinary albumin to creatinine ratio (UACR) in the Chinese community adults.
• RC is highly correlated with UACR, and at high RC level, the patients with critical values of blood pressure, BMI, and blood glucose has a more significant correlation between RC and UACR.

Highlights

• Both blood and renal infiltrated eosinophils were prevalent in DN and were associated with the severity of DN.
• IEA in renal pathology showed better fit in correlation with renal prognosis.
• Patients with IEA treated with steroids did not show renal benefit.

Highlights

• Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation due to underlying insulin resistance and other comorbidities including obesity, older age, hypertension, cardiovascular disease, and dyslipidemia.
• Insulin resistance, hyperglycemia, and elevated angiotensin-converting enzyme 2 (which acts as cellular “receptor” for the virus) leads to heightened inflammation in T2DM.
• We hypothesize that exacerbation of preexisting chronic inflammation and the intense hyperimmune response (“cytokine storm”) play a critical role in increased morbidity and mortality of coronavirus disease 2019 (COVID-19).
• Safe and rigorous blood glucose, blood pressure, and lipid control is recommended in patients with T2DM and COVID-19.

Highlights

• Type 2 diabetes mellitus (T2DM) patients with severe acute respiratory syndrome coronavirus 2 infection had more severe inflammation, coagulation activation, myocardia injury, hepatic injury, and kidney injury. T2DM aggravated the clinical status of coronavirus disease 2019 (COVID-19) patients and increased their critical illness rate and mortality.
• Glucocorticoid treatment and poor fasting blood glucose (≥11.1 mmol/L) control were found to be risk factors of fatality in T2DM patients with severe COVID-19.

Highlights

• Alternative kidney filtration markers may be particularly useful in adults with diabetes in which creatinine-based estimated glomerular filtration rate (eGFR) is biased.
• Lower levels of eGFR based on all filtration markers individually and combined as well as decline in eGFR_Cys, eGFR_Cr-Cys, eGFR_Cr-Cys-B2M were consistently associated with a higher risk of major macrovascular and microvascular events, together, and separately, and all-cause mortality.
• The addition of baseline levels or change in B2M-based eGFR improved the prediction of combined major macrovascular and microvascular events beyond creatinine.

Highlights

• A stable or even improved glycemic control was found in adolescents with T1DM using hybrid closed loop system not only during COVID-19 lockdown but also in the weeks after, when daily activities slowly resumed.
• Although the slowing down of routine daily activities might still have an influence, we believe that the continuation of the health care professional assistance through telemedicine during lockdown might have led to a “dragging effect” in these patients also after its suspension.