Based on the Web of Science database, the current status and trends of research on polymyositis (PM)/dermatomyositis (DM) with interstitial lung disease (ILD) (2000−2022) were analyzed in terms of annual publications, authors, institutions, countries, and keywords. The study found that researchers' interest in PM/DM with ILD has been increasing year by year, and the diagnosis, classification, autoantibodies, antibodies, prognosis, complications, and treatment of PM/DM with ILD have been a hot topic in the field. Anti-mda5 antibody, mortality, gene 5 antibody, idiopathic inflammatory myopathies, double-blind, and prognostic factors, among others, may be new hot topics.

Beneficial and harmful effects of IL22 in the intestine. IL-22 is produced by various immune cells at the intestinal epithelium. Here, it acts on enterocytes by binding to the IL-22 receptor complex to initiate its effects. These include inducing cell proliferation/tumorigenesis, wound healing, and induction of mucins by Goblet cells and antimicrobial peptides by Paneth cells. If produced in excessive amounts, these antimicrobial peptides may damage the intestinal epithelium and reduce microbial diversity. IL-22 induces tight junction proteins, modulating epithelial barrier permeability. IL-22 also induces Paneth cells differentiation in humans (image created with Biorender).

The current review summarizes changes in inflammatory biomarkers in adults after the use of electronic cigarettes. Cardiovascular, pulmonary, general, and oxidative-stress biomarkers reported in the extant literature on this topic are reviewed.

This systematic review aimed to investigate the role of the Fractalkin-CX3CL1/CX3CR1 axis as pro-inflammatory biomarkers to distinguish between periodontitis and rheumatoid arthritis and/or systemically healthy subjects.

Knockdown secreted phosphoprotein 1 (SPP1) inactivates the extracellular signal-regulated kinase (ERK) pathway.

This study demonstrated that extracellular vesicles derived from miR-9-enriched mesenchymal stem cells can freely cross the blood-brain barrier into the spinal cord tissue, and then target TLR4 receptors on the activated spinal cord glial cell membrane of interstitial cystitis/bladder pain syndrome (IC/BPS) model to inhibit the activation of NLRP3 inflammatorome and release of inflammatory factors, which can reduce neuron stimulation and restore neuron firing threshold, so as to desensitize neurons and achieve the purpose of treating bladder pain in IC/BPS patients.

High proteasome subunit alpha 5 (PSMA5) expression was observed in liver hepatocellular carcinoma (LIHC) tissues and associated with compromised survival of LIHC patients. PSMA5 knockdown inhibited migration and invasion of hepatocellular carcinoma (HCC) cells. PSMA5 knockdown in HCC cells downregulated PSMA5 in exosomes from these HCC cells.

We examined the inflammatory response of MPO^-/- mice with intestinal bacterial infection merely, hypoxia merely, and bacterial infection accompanied with hypoxia than those in wild-type mice to explore the role of MPO in innate immunity.

Sirtuin2 (Sirt2) is highly expressed in lamina propria Tregs. Sirt2 moderately suppresses Treg function but also inhibits Treg polarization toward Treg/Th17 cells and Th17 cells.

Before propensity-score matching, adalimumab achieves higher rates of clinical response, low disease activity, and remission than etanercept in rheumatoid arthritis patients. After matching, adalimumab still realizes a higher rate of clinical response than etanercept to some extent with equivalent safety in rheumatoid arthritis patients

Children with COVID-19 are characterized by distinct cytokine/chemokine/growth factor/acute phase protein markers that are markedly different from elderly COVID-19 individuals. CRP, C-reactive protein; IFN, interferon; IL, interleukin; PCA, principal component analysis; TGFα, transforming growth factorα; TNFα, tumor necrosis factorα.

The genetic determinants of severe acute respiratory syndrome coronavirus 2 in southern Bangladesh are not well understood. We investigated demographic variables, disease outcomes and genomic features of coronavirus disease 2019 patients. Missense (67.5%) and synonymous (18.31%) mutations and many unique mutations in S protein were highly noticed in adult patients with mild cases rather than severe cases.

Nuclear receptor subfamily five group A member two (NR5A2) has a critical role in the occurrence and progression of cutaneous squamous cell carcinoma (cSCC), and it may be played via the Wnt/β-catenin, at the same time, knockdown of NR5A2 expression mediates the effect of cisplatin in cSCC.

The classsical way and understanding for bone resoprtion and loss is mediated by the monocytes/macrophage-derived osteoclasts. The present study reveals a different alternative pathway for bone resorption and loss, which is done via the immature dendritic cell-derived osteoclasts with different phenotypic and factional activities: for example, through the step-wise cytokine cross talks, in an animal model of arthritic bone loss, in vivo

Allergic reactions to wheat appear later than milk during oral food challenge. For oral food challenge (OFC) for wheat, the dosing interval should be longer than 60 min.

In this study, we found that post-radiation mice showed significant lung inflammation and ferroptosis. Through the Nrf2/HO-1 pathway, dihydroartemisinin (DHA) prevented ferroptosis and reduced radiation-induced lung injury (RILI). According to our research, ferroptosis and the Nrf2/HO-1 pathway could be potential targets for the treatment of RILI, and DHA may be an applicable drug in RILI prevention and treatment

The inflammatory cell model of human mononuclear macrophage (THP-1) cells induced by lipopolysaccharide (LPS) was established to study the effect of Dexmedetomidine (DEX) on the expression of cell-related inflammatory factors. ADRA2A gene knockout THP-1 cells (THP-1KO) were constructed, and the effect of DEX on the expression of inflammatory factors of THP-1KO cells was detected. The target sites of DEX on β2 AR were screened by molecular docking. Reversion experiments were performed using ADRB2siRNA. The results showed that DEX significantly decreased the expression of MCP-1, interleukin-06, and IL-8 in THP-1 and THP-1KO cells induced by the LPS, and increased the level of IL-10. Immunofluorescence results showed that β2 adrenergic receptor (β2 AR) expression increased after DEX treatment. DEX significantly increased the activation of β2 AR and PKA/CREB pathways, inhibited the activation of NF-κB. ADRB2 siRNA reversed the effects of DEX and promoted the release of inflammatory cytokines

In patients with acute graft-versus-host disease (aGVHD), the expression of Tim-3 is significantly increased. Galectin-9 binding to Tim-3 may inhibit the activation of the PI3K/AKT pathway and enhance the function of Treg cells. On the other hand, transforming growth factor (TGF)-β promotes the differentiation of Treg cells through autocrine secretion, while TGF-β induces the expression of Galectin-9 in a paracrine manner. The increased Treg cells can inhibit the activation of Th1 and Th17 cells by secreting TGF-β, thus alleviating aGVHD and inducing immune tolerance

Cross-sectional type of study was conducted with the aim of detecting Newcastle disease virus (NDV). Convenience sampling method was used for sample data collection and a total of 348 serum samples were collected and indirect enzyme-linked immunosorbent assay (ELISA) tests were performed to detect antibodies against NDV and to determine its antibody titer. In the indirect ELISA test, 37.64% (131/348) were positive and antibody titer mean value of (1761.9088) was scored.

Present article discusses the rarity of ischemic stroke as the initial symptom of systemic lupus erythematosus (SLE), often leading to misdiagnosis. Through case reports and literature review, it emphasizes the need to consider SLE as a diagnosis in young patients with ischemic stroke, particularly in females with associated multisystem damage, for timely treatment and improved patient outcomes.

Our study highlights the usefulness of the C-reactive protein (CRP) to prognostic nutritional index (PNI) ratio in predicting the in-hospital mortality of severe fever with thrombocytopenia syndrome (SFTS) patients based on a cohort of 610 SFTS cases from Wuhan Union Hospital. Subsequent survival analysis demonstrates that CRP/PNI could well differentiate SFTS individuals with high risk from those with low risk. receiver operating characteristic (ROC) analysis unveils that CRP/PNI possesses nice predictive power for predicting the in-hospital mortality of SFTS. Briefly, CRP/PNI is a reliable biomarker that can serve as a promising predictor for subjects with SFTS.

Our study aimed to investigate the possibility of quercetin as a therapeutic agent for pneumonia and its role in the inflammatory response induced by lipopolysaccharide (LPS)，In conclusion, we found that quercetin attenuates LPS-induced inflammation in A549 by activating the nuclear factor erythroid 2 signaling pathway.

Intestinal epithelial apical–basal polarity plays a pivotal role in controlling epithelial AJs and TJs. Our data uncover the importance of polarity-related genes (especially PRKCZ) in CD pahtomechanism, that may facilitate the planning of the future studies looking for finding innovative diagnostic and therapeutic strategies for CD.

The systemic immune inflammation index (SII), derived from laboratory testing, serves as a risk factor for postoperative sepsis in patients with intestinal obstruction. With the increase of SII, the risk of postoperative sepsis is higher.

PPM1G was downregulated in hepatic IRI, thus promoting STING phosphorylation. PPM1G restricts macrophage M1 polarization.

Vitamin D can further inhibit the nuclear translocation of β-catenin by downregulating the expression of Wnt ligands (Wnt1 and Wnt3a), which reduces the expression of the downstream target gene cyclin D1. Systemic lupus erythematosus in mice was improved by inhibiting the activation of Wnt/β-catenin signal pathway.

Our findings indicated that Res attenuated dextran sulfate sodium-induced intestinal epithelial cells barrier dysfunction via activating nuclear factor erythroid-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1)pathway and had great therapeutic potential throughout the preliminary stages of colitis.

bisdemethoxycucurmin (BDMC) on osteoarthritis and to evaluate its regulatory role in the Nrf2 signaling pathway in chondrocytes, derived from the thyroid.

To describe immunogenecity, we checked potency of rabies vaccine. Single radial immunodiffusion method is in vitro, National Institutes of Health and fluorescent antibody virus neutralization is in vivo.

Our results confirm that Krüppel-like factor 4 can positively regulate the expression of TXNIP and regulate the pyroptosis process of ulcerative colitis through the TXNIP/NLRP3 pathway.

Our study demonstrated that adult patients with histiocytic necrotizing lymphadenitis-hemophagocytic lymphohistiocytosis showed distinct clinical, laboratory, and radiological features. And the prognosis is good and patients could be managed with steroids and supportive care.

Acute necrotic collection, acute peripancreatic fluid collection, pleural effusion, and ascites are common early complications of acute pancreatitis (AP). This study aimed to investigate the relationship between 12 cytokines and the early complications and severity of AP.

Our study demonstrates that HMGB1 can contribute to the pathogenesis of psoriasis by regulating Th17 cell differentiation through the HMGB1-TLR4-IL-23-RORγt pathway, then promote IL-17A production and aggravate inflammation process. Targeting HMGB1 may be a possible potential candidate for the immunotherapy of psoriasis.