The high presence of neutralizing antibodies against the SARS-CoV-2 spike protein among asymptomatic populations in N'Djamena could explain the low prevalence and low severity of Covid-19 observed in these areas, as these neutralizing antibodies play a key role in blocking SARS-Cov-2 infection. Moreover, the commercial tests available (Abbott Alinity i and Roche Elecsys®) for the detection of these receptor-binding domain antibodies (anti-RBDs) showed acceptable performance when compared with the pseudovirus neutralization test.

We conducted a cross-sectional study to estimate the seroprevalence of antibodies to SARS-CoV-2 in 820 participants from the general population of SRS during the COVID-19 pandemic and risk factors for disease and disease transmission The overall seroprevalence of COVID-19 was 41.7% (95% CI: 33.3%–47.6%). The highest prevalence was found in Goljano district (70%) and the lowest in Gunagado district (22.5%). Only age was found to be significantly associated with COVID-19 seropositivity. The high prevalence of COVID-19 combined with the low vaccination rate indicated that a large proportion of the population in SRS had been infected since the beginning of 2020 The key findings from the present study will have implications for shaping future epidemic control.

Our research may provide a reference for evaluating the pharmacological effect of these statin products on bone tissue in an inflammatory state, as well as a direction for the application of these drugs in the regulation of bone metabolism in infectious bone disease.

(1) This study adds evidence that macrophage activation syndrome (MAS) is a common and fatal complication of adult dermatomyositis in our cohort. MAS is closely related to RP-ILD in patients with dermatomyositis. (2) Clinicians should be aware that when RP-ILD is present in dermatomyositis patients with abnormal laboratory findings, such as cytopenia and hyperferritinemia, the presence of MAS should be considered.

The intervention of umbilical cord (UC)-mesenchymal stem cells (MSCs) and UC-MSC and derived exosomes improved intestinal homeostasis in NOD mice by increasing microbiota diversity and richness. Additionally, differential microbiota was significantly associated with Treg/Th17 cytokine levels.

Super natural killer cells derived from peripheral blood mononuclear cells have sufficiently activated mature characteristics and high antitumor activity, rendering them a highly promising and essential therapeutic approach for cancer treatment.

There are changes in serum cytokines and immune checkpoint molecules B7-1 and B7-H1 in pre-eclampsia (PE). However, these changes are not predictive of PE.

Glucocorticoid receptor beta may be used as a biomarker for disorders involving steroid resistance.

Dexmedetomidine (DEX) prevents nephritis by upregulating although sirtuin 3 (SIRT3) expression. The results of this study offer supporting information on the potential mechanism of DEX in its protection of the kidneys in lupus nephritis as well as the involvement of SIRT3 in this process.

COVID-19 infection can result in ovarian reserve injury by reducing the anti-Mullerian hormone (AMH) level but getting vaccinated against COVID-19 has no impact on the AMH level.

Five potential regulatory mechanisms of lncRNA-miRNA interactions: (1) lncRNAs repressing miRNA expression; (2) ceRNA; (3) co-expression of lncRNAs with miRNAs as primary-miRNAs; (4) miRNAs negatively regulating lncRNAs; (5) mutual repression between lncRNAs and miRNAs.

Peripheral γδT cells contribute to establishing immune tolerance in early pregnancy. Increased hCG concentrations in the blood circulation may not directly affected γδT cells functions because of the low expression of mannose receptor in γδT cells. However, when PBMCs incubated with hCG, certain pregnancy-relevant hCG concentrations can increase the ratios of Ki67+γδT cells, CD69⁺γδT cells, and IL-10⁺γδT cells, which might be dependent on the immune microenvironment modulation.

Lowly expressed LncRNA DANCR ameliorates the immune inflammatory response in rheumatoid arthritis (RA) by sponging miR-134-5p to activate its mediated Keap1-Nrf2/ARE signaling pathway, inhibiting the release of inflammatory factors from RA-fibroblast-like synoviocytes and stimulating antioxidant capacity

Low-dose IL-2 was promising and well-tolerated in treating systemic lupus erythematosus, which could promote Treg's proliferation and functional recovery. Injecting 0.5 million IU of IL-2 daily can better induce the differentiation of Treg cells and maintain immune homeostasis than injecting 1 million IU every other day.

Our experimental results show that HG stimulation upregulated miR-34a and suppressed cell viability by upregulating apoptosis in podocytes. MFN attenuates HG-stimulated cell death in podocytes by downregulating miR-34a. Additionally, our data showed that SIRT1 expression was positively correlated with MFN treatment and inversely correlated with miR-34a expression.

To analyze the structural characteristics of the intestinal flora of elderly Uyghur patients with Sarcopenia. There are significant differences in the composition of intestinal flora between elderly Uyghur patients with Sarcopenia and normal individuals

This study aimed to investigate the role of immunocompetence in chronic hepatitis B (CHB) patients with normal alanine transaminase (ALT) levels and negative hepatitis B e antigen (HBeAg) in the risk assessments of the progression of liver fibrosis. Age and Treg are independent risk factors for progressive liver fibrosis. Treg ≤ 6.875 indicates the need for timely antiviral treatment and can serve as an indicator for evaluating liver fibrosis.

This preclinical research validates that Nexrutine indeed plays protective role against inflammatory mucosal injury in UC, which is due at least in part to the transcriptional suppression of RELA.

Our report presents the findings of COVID-19 outcomes between the five boroughs of New York City, finding that Staten Island, a relatively affluent borough, had poor COVID-19 outcomes. Each zip code of Staten Island was analyzed for COVID-19 outcomes and social demographics in the form of social determinants of health were evaluated. Zip codes with more individuals with less than a high school degree, lower mean household income, and a higher proportion of households earning less than $25,000 a year had poorer COVID-19 outcomes. We believe that this report will be of particular interest to your readership, as it provides COVID-19 outcome analysis at the level of zip codes within Staten Island, suggesting differences in social determinants of health between various zip codes may explain the poor COVID-19 outcomes of the borough.

We investigated the eliciting dose for objective symptoms among various age groups, and determined the necessity of consuming the final dose step during an uneventful OFC to avoid false negative outcome.

circ_0087199 knockdown attenuated lipopolysaccharides-induced apoptosis, inflammation and oxidative stress of periodontal ligament cells by regulating the miR-527/toll-like receptor 4 pathway However, comprehensive roles of circ_0087199 in the pathophysiological processes of periodontitis should be analyzed because one circular RNAs usually has many target microRNAs. Additionally, in vivo data are lacking, and further investigation needs to be performed to provide in vivo evidence of circ_0087199 regulating periodontitis progression. Nevertheless, this work provides a theoretical basis for further drug administration of periodontitis.

This is an original study focused on mucosal immunity in IgA nephropathy. In this study, we retrieved mucosal immunity in the IgA nephropathy field from the Web of Science database and analyzed the literature characteristics and research hotspots using bibliometric analysis tools. This work provides readers with a scientific and comprehensive view of the structure of knowledge in the field of mucosal immunity in IgA nephropathy, providing research hotspots, frontiers, development trends, and a theoretical basis for subsequent scientific exploration.

Previous COVID-19 infection is associated with higher levels of SARS-CoV-2 antibodies following ChAdOx1 (AstraZeneca) vaccination. single dose of ChAdOx1 nCoV-19 administered post-SARS-CoV-2 infection serves as an effective immune booster

The aim of this study was to evaluate the clinical significance of quantitative detection of AMA-M2, anti-gp210 and anti-SP100 antibody levels in PBC.

Our study examined the transcriptomics after overexpression of CST1 and CCL26 separately in the alveoloar basal epithelial cell line A549 and observed a significant downregulation of type I and III interferons as well as interferon-stimulated genes. At protein level, the overexpression of CST1 and CCL26 induced a differentially expression of inflammatory proteins. Our results highlight the role of CST1 and CCL26 in asthma development due to their role in inflammation.

The purpose of this study was to explore the possibility of using Cordyceps cicadae as a potential therapeutic target for treating renal fibrosis damage in lupus nephritis. The current study's findings show that C. cicadae can alleviate renal fibrosis damage in lupus mice by targeting the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)-mediated autophagy pathway.

Immunosuppressant-treated neuromyelitis optica spectrum disorder (NMOSD) patients have a similar risk of COVID-19 infection to the general population. In immunosuppressant-treated NMOSD patients, COVID-19 disease duration is shorter and clinical symptoms are less severe. In addition, NMOSD patients treated with hUC-MSC had favorable COVID-19 outcomes with no increased risk of severe COVID-19.